| 方琼.不同化疗阶段乳腺癌生活质量现状及相关影响因素[J].上海护理,2019,19(9): |
| 不同化疗阶段乳腺癌生活质量现状及相关影响因素 |
| Study on quality of life and related factors in different stages of chemotherapy for breast cancer |
| DOI： |
| 中文关键词: 乳腺癌、化疗、生活质量、影响因素 |
| 英文关键词:Breast cancer Chemotherapy quality of life Influence factors |
| 基金项目:上海市科学技术委员会科研计划项目,编号：16411951100；上海市教委护理高原学科项目（Hlgy15001yjx） |
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| 中文摘要: |
| 目的 了解接受辅助化疗乳腺癌患者不同阶段生活质量现状、变化趋势以及影响化疗末期生活质量的相关因素。方法 运用人体学测量、FACT-B中文版和国际体力活动评价量表，对首次接受辅助化疗乳腺癌患者进行纵向跟踪测量和问卷调查。结果 调查中乳腺癌患者整个化疗期间生活质量总分平均值为96.34±14.71分，其中化疗前生活质量总分最低（93.41±13.65），伴随化疗进展患者在生活质量总分、生理状况维度、情感状况维度、功能状况维度和附加关注维度得分变化有显著差异（P＜0.001）；经多元线性回归分析显示化疗药物、体力活动、有无肥胖和职业状态是预测本组乳腺癌患者化疗末期生活质量的重要因素。结论 化疗影响乳腺癌患者的生活质量，临床护理人员对使用蒽环类化疗药物、缺乏体力活动、肥胖以及退休/无业患者应该给予更多关注，促进患者在化疗期间合理活动、控制体重有益于提高患者生活质量。 |
| 英文摘要: |
| Objective: To describe the situation、change and influence factors on the quality of life of early stage breast cancer patients during chemotherapy. Patients and Methods: Anthropometric measurements, FACT-B Chinese version and international physical activity evaluation scale were used to conduct longitudinal follow-up and questionnaire survey carried on pre(after operation)、middle and after chemotherapy for breast cancer patients. Results: The follow up for the quality of life in previously chemotherapy na?ve breast cancer patients demonstrated that the average life quality score was 96.34 ± 14.71 during chemotherapy. The lowest life quality score was observed before chemotherapy (93.41±13.65). For different measuring points during chemotherapy, not only the total score of life quality, but also the emotional, functional and additional concern dimensions were differently distributed (P < 0.001). Multinomial logistic regression indicated that chemotherapy agents (taxol B = 8.98,P = 0.011; anthracycline followed by taxol B = 10.03, P = 0.003; others B = 11.00, P = 0.010), abundant physical activity during late phase (B = 7.47, P = 0.004), obesity in middle phase of chemotherapy (B = -7.27, P = 0.001) and retirement/unemployed (B = -3.97, P = 0.045) were independent impact factors for late phase quality of life. Conclusions: The quality of life of patients with breast cancer during chemotherapy is higher than that of previous studies, and the quality of life of patients at the end of chemotherapy is higher than that before chemotherapy. Clinical nurses should pay more attention to the use of anthracycline, lack of physical activity, obesity, and retired patients. Through guiding the patients in the period of chemotherapy reasonable activities, control weight to promote the quality of life of patients. |
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