| 朱静艳,陈薇.优化注射用紫杉醇(白蛋白结合型)配制、运送方法的效果评价[J].上海护理,2021,21(S1): |
| 优化注射用紫杉醇(白蛋白结合型)配制、运送方法的效果评价 |
| Evaluation on the effect of optimizing the preparation and delivery method of paclitaxel for injection (Albumin Bound) |
| DOI： |
| 中文关键词: 注射用紫杉醇（白蛋白结合型） 优化配制方法 优化运送方式 效果评价 |
| 英文关键词:Paclitaxel for injection (Albumin Bound) Optimizing the preparation method Optimizing the transportation mode Effect Evaluation |
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| 中文摘要: |
| 目的 注射用紫杉醇（白蛋白结合型）由于人血白蛋白的特性在配制各环节极易产生泡沫影响药物剂量的准确性，本文通过优化原有药品说明书上的配制方法、规范化的培训、选择合适的配送方式及异常情况的处置等措施减少泡沫产生以保证药量。方法 取2018年10月-2019年9月本院PIVAS配制的注射用紫杉醇（白蛋白结合型）268支，剂量100mg/支，配制含极量浓度100mg/20ml的成品输液80袋（其中300mg/60ml共计48袋,400mg/80ml共计30袋,200mg/40ml共计2袋），按随机分对照组、观察组各40例。配制效果比较：对照组按说明书操作方法，使用普通注射器配制。观察组根据配制中影响药物剂量准确性的因素进行改进的优化配制方法、规范培训、选择密闭性良好的注射器进行配制。运送效果比较：对照组29例I级配制效果的成品输液袋专用车人工运送，观察组38例I级配制效果成品输液袋随机抽取29例专用箱人工运送，用统计学方法对两组配制效果、运送效果及临床科室对配制质量满意度进行比较。 结果 两组各40例配制效果比较：对照组的合格配制率（72.5%）明显低于观察组（95%），两组各29例成品输液袋运送效果比较：对照组的配送合格率（62.1%)明显低于观察组（89.7%）；两组满意度比较观察组明显高于对照组，两组比较差异有统计学意义（P＜0.05）。 结论 由于药物的特殊性在配制、运送的各环节均会导致泡沫的产生而影响药物配制的浓度及剂量，本研究通过优化配制方法及相应的措施，达到较好的效果，确保药物配制剂量的准确性，保证疗效。 |
| 英文摘要: |
| Objective Paclitaxel for injection (Albumin Bound) is prone to foam in every preparation step due to the characteristics of human serum albumin, which affects the accuracy of drug dosage. This paper reduces the guaranteed dosage of foam by optimizing the preparation method in the original drug instructions, standardizing training, selecting appropriate distribution methods and handling abnormal situations. Methods From October 2018 to September 2019, 268 paclitaxel for injection (Albumin Bound) prepared by PIVAS in our hospital, with a dose of 100mg/piece, were prepared into 80 bags of finished infusion with extreme concentration of 100mg/20ml (including 48 bags of 300mg/60ml, 30 bags of 400mg/80ml and 200mg/40ml) Comparison of preparation effect: the control group was prepared by ordinary syringe according to the instruction. In the observation group, according to the factors affecting the accuracy of drug dosage, we improved the optimal preparation method, standardized training, and selected syringes with good airtightness for preparation. Comparison of delivery effect: 29 cases of finished infusion bags with grade I preparation effect were manually delivered by special vehicles in the control group, and 29 cases of finished infusion bags with grade I preparation effect were randomly selected by special boxes in the observation group. Statistical methods were used to compare the preparation effect, delivery effect and clinical departments' satisfaction with preparation quality between the two groups. Results Comparison of preparation effect of 40 cases in two groups: the qualified preparation rate of control group (72.5%) was significantly lower than that of observation group (95%); comparison of delivery effect of finished infusion bags of 29 cases in two groups: the distribution qualified rate of control group (62.1%) was significantly lower than that of observation group (89.7%); The satisfaction of the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant (P < 0.05). Conclusion Because of the particularity of drugs, foam will be produced in every link of preparation and transportation, which will affect the concentration and dosage of drug preparation. By optimizing the preparation method and corresponding measures, this study can achieve better results and ensure the accuracy of drug preparation dosage and curative effect. |
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